Infectious Diseases

M Papaianni received her Bachelor’s Degree from Biology at the University of Naples “Federico II” and Master Degree from Biology at the University of Benevento “Università del Sannio” her study experiences continued thanks to PhD student in Biotechnology  of the XXXII cycle. Her scientific curiosity and the strong attitude for research have always allowed me to distinguish myself in my projects.

Bacteria are under constant attack by bacteriophages (phages), the most abundant life forms in the biosphere. This work describes how the phage therapy is an efficient way to contrast the bacterial infection regardless the host. Here, we describe the activity of phage in both plant and chicken meat. All the experiment carried out are with phage complex with the hydroxyapatite, since many years, hydroxyapatite is being explored as vehicle for drug targeting, transfection, bone scaffolds and implant coating materials and for these reasons we evaluated the effect of this mineral for the bacteriophage therapy. At first, we validated the antimicrobial activity of the phage and its possible direct administration into the plant xylem. We next performed both in vivo and in vitro experiments to assess the activity of the bacteriophage in association with hydroxyapatite, secondly, we demonstrate that the hydroxyapatite/ bacteriophage complex was able to reduce the bacterial load of Salmonella Rissen in previously infected minced meat, respective to bacteriophage or hydroxyapatite alone